Sodium borohydride → (6-Chloro-2-methylpyridin-3-yl)methanol

HRID 385945Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 385945
[BH4-].[Na+].[Cl:3][C:4]1[CH:11]=[CH:10][C:7]([CH:8]=[O:9])=[C:6]([CH3:12])[N:5]=1>CO>[Cl:3][C:4]1[N:5]=[C:6]([CH3:12])[C:7]([CH2:8][OH:9])=[CH:10][CH:11]=1

Komponenten

4

Edukt 2

HCID 4311764Sodium borohydrideHCID 447548676-Chloro-2-methylpyridine-3-carbaldehyde

Produkt 1

HCID 59525984(6-Chloro-2-methylpyridin-3-yl)methanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Sodium borohydride (0.73 g, 19.28 mmol) was added to a solution of 6-chloro-2-methylnicotinaldehyde (1.5 g, 9.64 mmol) in methanol (38.6 mL) at room temperature. The mixture was stirred for 2 hours, then quenched with water and saturated aqueous sodium bicarbonate, and extracted three times with ethyl acetate. The organic layers were combined, dried over magnesium sulfate, filtered, and concentrated under reduced pressure to afford the title compound.

Aufarbeitung

  1. customquenched with water and saturated aqueous sodium bicarbonate
  2. extractionextracted three times with ethyl acetate
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-793b09812c5f4bde9dc40ab0690a36f3
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08367706B2

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