Ethyl bromoacetate → Ethyl[(6-chloro-2-methylpyridin-3-yl)methoxy]acetate
Reaktionsgleichung
[H-].[Na+].[Cl:3][C:4]1[N:9]=[C:8]([CH3:10])[C:7]([CH2:11][OH:12])=[CH:6][CH:5]=1.Br[CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16]>O1CCCC1.O>[CH2:18]([O:17][C:15](=[O:16])[CH2:14][O:12][CH2:11][C:7]1[C:8]([CH3:10])=[N:9][C:4]([Cl:3])=[CH:5][CH:6]=1)[CH3:19]Komponenten
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Reaktionsbedingungen
- Temperatur
- 0 °C
Versuchsvorschrift
Sodium hydride (266 mg of 60%, 6.66 mol) was suspended in tetrahydrofuran (14.8 mL) and cooled to 0° C. (6-Chloro-2-methylpyridin-3-yl)methanol (Example 421 Step 1) (350 mg, 2.22 mmol) was added and the mixture was stirred for 30 minutes at 0° C. Ethyl bromoacetate (0.25 mL, 2.22 mmol) was added and the solution was heated to 50° C. for 4 hours. The reaction mixture was then cooled to ambient temperature, diluted with water, and extracted with ethyl acetate. The aqueous layer was acidified with 1N HCl and extracted with ethyl acetate three times. All the organic layers were combined, dried over magnesium sulfate, filtered, concentrated, and purified via silica gel chromatography (0-100% ethyl acetate in hexane) to afford the title compound.
Aufarbeitung
- additionwas added
- temperaturethe solution was heated to 50° C. for 4 hours
- temperatureThe reaction mixture was then cooled to ambient temperature
- extractionextracted with ethyl acetate
- extractionextracted with ethyl acetate three times
- dry with materialdried over magnesium sulfate
- filtrationfiltered
- concentrationconcentrated
- custompurified via silica gel chromatography (0-100% ethyl acetate in hexane)
Quellen und Nachweise
- ORD-Eintrag
- ord-9c0915778b7f4cab9abab802d34860c8
- Quelldatensatz
- uspto-grants-2013_02
- Patentnummer
- US08367706B2
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