Trityl chloride → Dimethyl 1-trityl-3,5-pyrazoledicarboxylate

HRID 386347

Reaktionsgleichung

Reaktionsgleichung von HRID 386347
C(OC(C1C=NN([C:11]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)C=1)=O)C.[CH3:30][O:31][C:32]([C:34]1[CH:38]=[C:37]([C:39]([O:41][CH3:42])=[O:40])[NH:36][N:35]=1)=[O:33].[H-].[Na+].C(Cl)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>CN(C)C=O>[C:11]([N:36]1[C:37]([C:39]([O:41][CH3:42])=[O:40])=[CH:38][C:34]([C:32]([O:31][CH3:30])=[O:33])=[N:35]1)([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)([C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Komponenten

6

Edukt 4

HCID 6456Trityl chlorideHCID 24758Sodium hydrideHCID 14844913,5-dimethyl 1H-pyrazole-3,5-dicarboxylateHCID 10523968Ethyl 1-tritylpyrazole-4-carboxylate

Produkt 1

HCID 12377531Dimethyl 1-trityl-3,5-pyrazoledicarboxylateAusbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

This compound is a white microcrystalline solid that has been isolated following the methodology described in 2b for ethyl-1-tritylpyrazole-4-carboxylate, by reaction of with dimethyl-3,5-pyrazoledicarboxylate (1.411 g, 7.66 mmol) with sodium hydride (250 mg, 10.41 mmol) in dry dimethylformamide (20 mL), followed by treatment with trityl chloride (2.135 g, 7.66 mmol). Yield: 98% (3.200 g, 7.50 mmol).

Aufarbeitung

  1. customhas been isolated

Quellen und Nachweise

ORD-Eintrag
ord-1def85f374cc41fbb0a7d03b5349c89d
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08372379B2

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