(S)-4-(1-Cyclopropyl-2-methoxyethyl)-6-(6-methoxy-2,5-dimethylpyridin-3-ylamino)-5-oxo-4,5-dihydropyrazine-2-carbonitrile → HCID 178495711, Verbindung

HRID 386509Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 386509
[CH:1]1([C@H:4]([N:8]2[C:13](=[O:14])[C:12]([NH:15][C:16]3[C:17]([CH3:25])=[N:18][C:19]([O:23]C)=[C:20]([CH3:22])[CH:21]=3)=[N:11][C:10]([C:26]#[N:27])=[CH:9]2)[CH2:5][O:6][CH3:7])[CH2:3][CH2:2]1>C(O)(=O)C>[CH:1]1([C@H:4]([N:8]2[C:13](=[O:14])[C:12]([NH:15][C:16]3[C:17]([CH3:25])=[N:18][C:19]([OH:23])=[C:20]([CH3:22])[CH:21]=3)=[N:11][C:10]([C:26]#[N:27])=[CH:9]2)[CH2:5][O:6][CH3:7])[CH2:3][CH2:2]1

Komponenten

3

Edukt 1

HCID 44596700(S)-4-(1-Cyclopropyl-2-methoxyethyl)-6-(6-methoxy-2,5-dimethylpyridin-3-ylamino)-5-oxo-4,5-dihydropyrazine-2-carbonitrile

Produkt 1

HCID 178495711HCID 178495711, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

(S)-4-(1-Cyclopropyl-2-methoxyethyl)-6-(6-methoxy-2,5-dimethylpyridin-3-ylamino)-5-oxo-4,5-dihydropyrazine-2-carbonitrile (3.00 g, 8.12 mmol) and KI (6.2 g, 37.3 mmol) in glacial acetic acid (80 mL) was heated at 100° C. with stirring for 1 h. LC-MS analysis indicated >98% conversion to the required product. The reaction mixture was cooled to ambient temperature and acetic acid was evaporated in vacuo. The residue was partitioned between ethyl acetate (3×150 mL) and H2O (˜100 mL). The organic layer was washed with brine (100 mL) and then dried over Na2SO4. The organic layer was evaporated in vacuo and the dark brown residue was purified by Biotage SiO2 column chromatography (5% MeOH/CH2Cl2, Rf=0.16) to give pure (S)-4-(1-cyclopropyl-2-methoxyethyl)-6-(6-hydroxy-2,5-dimethylpyridin-3-ylamino)-5-oxo-4,5-dihydropyrazine-2-carbonitrile (2.33 g, 81%) as pale yellow solid: 1H NMR (CDCl3) δ 7.85-7.55 (br. s, 1H), 7.48 (s, 1H), 4.16-4.12 (m, 1H), 3.73 (dd, 1H, JAB=10.3 Hz, JAX=4.9 Hz), 3.66 (dd, JBX=2.2 Hz), 3.35 (s, 3H), 2.40-2.20 (br s, 6H), 1.39-1.32 (m, 1H), 0.85-0.79 (m, 1H), 0.67-0.61 (m, 1H), 0.55-0.51 (m, 1H), 0.34-0.29 (m, 1H); LRMS (ESI) m/e 356 [(M+H)+, calcd for C18H21N5O3 356]; tR=1.8 min (Solvent A: MeOH:H2O:TFA=10:90:0.1; Solvent B: MeOH:H2O:TFA=90:10:0.1; 0% B in A to 100% B in A linear gradient in a 3 min run with 1 min hold time at the end, λ=280 nm).

Quellen und Nachweise

ORD-Eintrag
ord-1f9b8f8fdf7f44c18fc6b3d3d7ded101
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08372847B2

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