Acetone → 4-(3-Methoxy-4-ethoxyphenyl)-3-buten-2-one

HRID 38668

Reaktionsgleichung

Reaktionsgleichung von HRID 38668
[OH-].[Na+].[CH3:3][O:4][C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][C:12]=1[O:13][CH2:14][CH3:15])[CH:8]=O.Cl.[CH3:17][C:18]([CH3:20])=[O:19]>C(O)C.O>[CH3:3][O:4][C:5]1[CH:6]=[C:7]([CH:8]=[CH:17][C:18](=[O:19])[CH3:20])[CH:10]=[CH:11][C:12]=1[O:13][CH2:14][CH3:15]

Komponenten

7

Edukt 4

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 671164-Ethoxy-3-methoxybenzaldehyde

Produkt 1

HCID 692481204-(3-Methoxy-4-ethoxyphenyl)-3-buten-2-oneAusbeute 66,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

10% sodium hydroxide aqueous (40 ml) was added under stirring to a solution of 3-methoxy-4-ethoxybenzaldehyde (9.09 g, 50 mmol) in acetone (25 ml), 95% ethanol (25 ml) and water (200 ml). The reaction mixture was stirred for 24 hr at room temperature, after the reaction completed, the reaction mixture was neutralized with 6N hydrochloric acid to adjust pH=7.0. The precipitated solid was collected by filtrating and washed with water and ethanol successively, dried, and then recrystallized from 95% ethanol to give 7.38 g of a pale yellow solid, mp: 95-97° C., yield: 66.5%.

Aufarbeitung

  1. customThe precipitated solid was collected
  2. filtrationby filtrating
  3. washwashed with water and ethanol successively
  4. customdried
  5. customrecrystallized from 95% ethanol

Quellen und Nachweise

ORD-Eintrag
ord-494e067128284a1eb05853ce0472705c
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08524744B2

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