m-Chloroperbenzoic acid → (2'-Benzenesulfinylmethyl-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid

HRID 38695Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 38695
[CH3:1][O:2][C:3]1[C:8]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][C:10]=2[CH2:19][S:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[CH:7][C:6]([CH2:27][C:28]([OH:30])=[O:29])=[CH:5][CH:4]=1.ClC1C=C(C=CC=1)C(OO)=[O:36]>ClCl>[C:21]1([S:20]([CH2:19][C:10]2[CH:11]=[C:12]([C:15]([F:18])([F:16])[F:17])[CH:13]=[CH:14][C:9]=2[C:8]2[C:3]([O:2][CH3:1])=[CH:4][CH:5]=[C:6]([CH2:27][C:28]([OH:30])=[O:29])[CH:7]=2)=[O:36])[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

Komponenten

4

Edukt 2

HCID 70297m-Chloroperbenzoic acidHCID 45136825(6-Methoxy-2'-phenylsulfanylmethyl-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid

Produkt 1

HCID 45280348(2'-Benzenesulfinylmethyl-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 24526ChlorineLösungsmittel

Versuchsvorschrift

To (6-methoxy-2′-phenylsulfanylmethyl-4′-trifluoromethyl-biphenyl-3-yl)-acetic acid (0.030 g, 0.07 mmol) in CH2 Cl2 was added 3-chloroperoxybenzoic acid (0.015 g, 0.07 mmol), and the reaction was stirred at room temperature for 20 minutes. The mixture was concentrated, and the residue was purified by preparative HPLC to give the title compound.

Aufarbeitung

  1. concentrationThe mixture was concentrated
  2. customthe residue was purified by preparative HPLC

Quellen und Nachweise

ORD-Eintrag
ord-6bf1aaa5092049619ee7e417e4db224b
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08524748B2

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