Phosgene → Carbamic chloride, N-ethyl-N-(phenylmethyl)-

HRID 38696Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 38696
[CH2:1]([NH:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH3:2].C(N(C(C)C)CC)(C)C.[C:20](Cl)([Cl:22])=[O:21]>C(Cl)Cl>[CH2:4]([N:3]([CH2:1][CH3:2])[C:20]([Cl:22])=[O:21])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Komponenten

5

Edukt 3

HCID 6371PhosgeneHCID 81531DiisopropylethylamineHCID 84352N-Ethylbenzylamine

Produkt 1

HCID 10679448Carbamic chloride, N-ethyl-N-(phenylmethyl)-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

N-Ethylbenzylamine (0.56 mL, 3.8 mmol) and diisopropylethylamine (1 mL, 5.7 mmol) were combined in CH2Cl2 (12 mL) and cooled to 0° C. Phosgene (1.9M in toluene; 2.4 mL, 4.6 mmol) was added over 5 minutes, and the reaction was stirred at room temperature overnight. The mixture was concentrated, and the residue was diluted with diethyl ether (150 mL) and washed twice with H2O. The organic layer was dried and concentrated to give the title compound.

Aufarbeitung

  1. concentrationThe mixture was concentrated
  2. additionthe residue was diluted with diethyl ether (150 mL)
  3. washwashed twice with H2O
  4. customThe organic layer was dried
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-ba028587e25a48428392e51037537357
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08524748B2

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