HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-(2,3-Xylyl)piperazine → 1-(2,3-dimethylphenyl)-4-(3-(1,5-diphenyl-1H-pyrazol-3-yl)propyl)piperazine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-(2,3-Xylyl)piperazine | HCID 70541 | — |
| Edukt | Diisopropylethylamine | HCID 81531 | — |
| Edukt | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Edukt | 3-(1,5-diphenyl-1H-pyrazol-3-yl)propanal | HCID 42631135 | — |
| Produkt | 1-(2,3-dimethylphenyl)-4-(3-(1,5-diphenyl-1H-pyrazol-3-yl)propyl)piperazine | HCID 25065049 | — |
Reaktionsschritte
77 mg (81%) of target compound was obtained by using a method same as in Example 1 by using 3-(1,5-diphenyl-1H-pyrazol-3-yl)propanal (64 mg, 0.231 mmol), 1-(2,3-dimethylphenyl)piperazine (40 mg, 0.210 mmol), DIPEA (0.037 mL, 0.210 mmol) and NaBH(OAc)3 (156 mg, 0.735 mmol).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08372844B2 |
| Quelldatensatz | uspto-grants-2013_02 |
| ORD ID | ord-b5673ea7824540dc901c271c560f168a |
| Quellennotiz | uspto-grants-2013_02 |