Lithium Hydroxide → 5-bromo-3-[(1,1-dioxidotetrahydro-3-thienyl)methyl]-1H-indole-7-carboxylic acid
Reaktionsgleichung
[OH-].[Li+].[Br:3][C:4]1[CH:5]=[C:6]2[C:10](=[C:11]([C:13]([O:15]CC)=[O:14])[CH:12]=1)[NH:9][CH:8]=[C:7]2[CH2:18][CH:19]1[CH2:23][CH2:22][S:21](=[O:25])(=[O:24])[CH2:20]1>CO>[Br:3][C:4]1[CH:5]=[C:6]2[C:10](=[C:11]([C:13]([OH:15])=[O:14])[CH:12]=1)[NH:9][CH:8]=[C:7]2[CH2:18][CH:19]1[CH2:23][CH2:22][S:21](=[O:24])(=[O:25])[CH2:20]1Komponenten
4
Versuchsvorschrift
An aqueous solution of lithium hydroxide (0.64 g, 26.49 mmol) was added to a solution of ethyl 5-bromo-3-[(1,1-dioxidotetrahydro-3-thienyl)methyl]-1H-indole-7-carboxylate (3.52 g, 8.83 mmol) in methanol (100 mL) at room temperature. The mixture was heated at reflux for 1 h and then concentrated. The residue was washed with water, acidified with 1N HCl (pH ˜3), and filtered, giving the title compound.