Hydrochloric Acid → HCID 178519917, Verbindung

HRID 38731

Reaktionsgleichung

Reaktionsgleichung von HRID 38731
[CH:1]([C:3]1[N:4]=[C:5]([CH:8]2[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)[S:6][CH:7]=1)=[O:2].[ClH:21]>O1CCOCC1>[Cl-:21].[CH:1]([C:3]1[N:4]=[C:5]([CH:8]2[CH2:13][CH2:12][NH2+:11][CH2:10][CH2:9]2)[S:6][CH:7]=1)=[O:2]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 7172298tert-Butyl 4-(4-formyl-1,3-thiazol-2-yl)piperidine-1-carboxylate

Produkt 1

HCID 178519917HCID 178519917, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

To tert-butyl 4-(4-formyl-1,3-thiazol-2-yl)piperidine-1-carboxylate (10 g) was added dropwise, at 0° C. a 4 molar solution of hydrogen chloride in 1,4-dioxane (100 ml). The reaction mixture was stirred at 0° C. and then gradually warmed to room temperature. After stirring overnight, the solvent and excess hydrogen chloride were removed. This gave 4-(4-formyl-1,3-thiazol-2-yl)piperidinium chloride (9 g).

Aufarbeitung

  1. temperaturegradually warmed to room temperature
  2. stirringAfter stirring overnight
  3. customthe solvent and excess hydrogen chloride were removed

Quellen und Nachweise

ORD-Eintrag
ord-7edf2078af034c5e8e68ff894daec008
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08524743B2

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