4-Isothiocyanato-2-(trifluoromethyl)benzonitrile → N-Desmethylenzalutamide

HRID 38756

Reaktionsgleichung

Reaktionsgleichung von HRID 38756
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([CH3:17])([CH3:16])[C:12]([O:14]C)=O)=[CH:6][C:5]=1[F:18])(=[O:3])[NH2:2].[F:19][C:20]([F:33])([F:32])[C:21]1[CH:28]=[C:27]([N:29]=[C:30]=[S:31])[CH:26]=[CH:25][C:22]=1[C:23]#[N:24]>CS(C)=O.O>[C:23]([C:22]1[CH:25]=[CH:26][C:27]([N:29]2[C:12](=[O:14])[C:11]([CH3:17])([CH3:16])[N:10]([C:7]3[CH:8]=[CH:9][C:4]([C:1]([NH2:2])=[O:3])=[C:5]([F:18])[CH:6]=3)[C:30]2=[S:31])=[CH:28][C:21]=1[C:20]([F:19])([F:32])[F:33])#[N:24]

Komponenten

5

Edukt 2

HCID 116155404-Isothiocyanato-2-(trifluoromethyl)benzonitrileHCID 66617687Alanine, N-[4-(aminocarbonyl)-3-fluorophenyl]-2-methyl-, methyl ester

Produkt 1

HCID 70678916N-Desmethylenzalutamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 679Dimethyl SulfoxideLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of methyl 2-(4-carbamoyl-3-fluorophenylamino)-2-methylpropanoate and 2-(trifluoromethyl)-4-isothiocyanatobenzonitrile (1.5 equivalents) in dry DMSO (5 mL per mmol) was heated to 80-82° C. for 12 h. The reaction mixture was diluted with water and extracted with ethyl acetate. The combined organic layer was concentrated under reduced pressure and the residue was purified by silica gel chromatography eluting with 40% Acetone-Hexanes. MS (m/z): 451 (M+1). HPLC: Column, YMC ODS A, 4.6×150 mm, 5 μm, Mobile Phase A:10 mM Ammonium acetate, Mobile Phase B: Acetonitrile, Gradient, 10% B up to 2 min, 10% to 90% B in 3 min, hold for 3 min, 90% to 10% B in 5 min, Retention time, 2.782 min, HPLC Purity, 99.4%, Flow Rate, 1 mL/min. 1H NMR (CDCl3, Freebase): δ (ppm) 8.3 (t, 1H), 8.0 (d, 1H) 7.98 (s, 1H), 7.8 (d, 1H), 7.27 (d, 1H), 7.2 (d, 1H), 6.65 (d, 1H), 6.0 (s, 1H), 1.62 (s,6H).

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. concentrationThe combined organic layer was concentrated under reduced pressure
  3. customthe residue was purified by silica gel chromatography
  4. washeluting with 40% Acetone-Hexanes
  5. wait10% to 90% B in 3 min
  6. waithold for 3 min
  7. wait90% to 10% B in 5 min
  8. customRetention time, 2.782 min, HPLC Purity, 99.4%, Flow Rate, 1 mL/min

Quellen und Nachweise

ORD-Eintrag
ord-5e358dae823b4bd29d7a4dcebbbfc529
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08524755B2

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