2,6-Lutidine → 4-(3-fluoro-4-nitrophenoxy)-6-phenyl-7H-pyrrolo[2,3-d]pyrimidine

HRID 387785Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 387785
[F:1][C:2]1[CH:3]=[C:4]([OH:11])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].N1C(C)=CC=CC=1C.CN1CCCC1.Cl[C:27]1[C:28]2[CH:35]=[C:34]([C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=3)[NH:33][C:29]=2[N:30]=[CH:31][N:32]=1>O>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9])[O:11][C:27]1[C:28]2[CH:35]=[C:34]([C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=3)[NH:33][C:29]=2[N:30]=[CH:31][N:32]=1

Komponenten

6

Edukt 4

HCID 79372,6-LutidineHCID 84541-MethylpyrrolidineHCID 5209483-Fluoro-4-nitrophenolHCID 224844424-chloro-6-phenyl-7H-pyrrolo[2,3-d]pyrimidine

Produkt 1

HCID 589311924-(3-fluoro-4-nitrophenoxy)-6-phenyl-7H-pyrrolo[2,3-d]pyrimidineAusbeute 20,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
130 °C

Versuchsvorschrift

After adding 328 mg of 3-fluoro-4-nitrophenol, 0.22 ml of 2,6-lutidine and 0.9 ml of N-methylpyrrolidine to 360 mg of the 4-chloro-6-phenyl-7H-pyrrolo[2,3-d]pyrimidine described in WO97/02266 and PCT/EP96/02728 and stirring the mixture overnight at 130° C., it was returned to room temperature, water was added, the precipitated solid was filtered out and washed with water and diethyl ether, and the collected solid was dried to obtain 112 mg of the title compound.

Aufarbeitung

  1. customwas returned to room temperature
  2. filtrationthe precipitated solid was filtered out
  3. washwashed with water and diethyl ether
  4. customthe collected solid was dried

Quellen und Nachweise

ORD-Eintrag
ord-9070e1acbcee479da2ca06cd974061de
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08372981B2

Notizen zur Reaktion

Wird geladen…