Dimethylformamide → (Tetrahydro-2H-pyran-4-yl)acetyl chloride

HRID 38787Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 38787
[O:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]([OH:10])=O)[CH2:3][CH2:2]1.CN(C)C=O.C(Cl)(=O)C([Cl:19])=O>ClCCl>[O:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]([Cl:19])=[O:10])[CH2:3][CH2:2]1

Komponenten

5

Edukt 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 2773575Tetrahydropyran-4-ylacetic acid

Produkt 1

HCID 24229747(Tetrahydro-2H-pyran-4-yl)acetyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a mixture of tetrahydro-2H-pyran-4-ylacetic acid (89 mg), N,N-dimethyl formamide (1 μL), and dichloromethane (1 mL) was added oxalylchloride (54 μL), and the mixture was stirred at room temperature for 2 hours. The reaction liquid was concentrated under reduced pressure, and then toluene (1 mL) was added thereto, followed by further concentration under reduced pressure, to obtain crude tetrahydro-2H-pyran-4-yl acetyl chloride.

Aufarbeitung

  1. customThe reaction liquid
  2. concentrationwas concentrated under reduced pressure
  3. additiontoluene (1 mL) was added
  4. concentrationfollowed by further concentration under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-555ce1cf5e494e17afab4008bd8bce25
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08524727B2

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