Ethanol → HCID 24985023, Verbindung

HRID 388131Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 388131
[C:1]1([C@H:7]([NH:9][C:10]2[C:15]([N+:16]([O-])=O)=CN=[C:12]([C:19]3[CH:28]=[CH:27][CH:26]=[C:25]4[C:20]=3[CH:21]=[CH:22][CH:23]=[N:24]4)[CH:11]=2)[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1([C@H](NC2C=C(C3C=CC=C4C=3C=CC=N4)N=C[C:39]=2[NH2:54])C)C=CC=CC=1.[H][H].[CH2:57]([OH:59])C>[Pd]>[C:1]1([C@H:7]([N:9]2[C:10]3[C:15](=[N:54][CH:39]=[C:12]([C:19]4[CH:28]=[CH:27][CH:26]=[C:25]5[C:20]=4[CH:21]=[CH:22][CH:23]=[N:24]5)[CH:11]=3)[NH:16][C:57]2=[O:59])[CH3:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

5

Edukt 3

HCID 702EthanolHCID 86626409HCID 86626409, VerbindungHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 24985023HCID 24985023, VerbindungAusbeute 97,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23938PalladiumKatalysator

Versuchsvorschrift

((1R)-1-phenylethyl)(3-amino-6-(5-quinolyl)(4-pyridyl))amine ((1R)-1-Phenylethyl)(5-nitro-2-(5-quinolyl)(4-pyridyl))amine (500 mg, 1.35 mmol) was dissolved in ethanol (100 mL). Palladium on carbon (70 mg) was added followed by a hydrogen balloon. The reaction was stirred at room temperature for 18 h, then filtered through celite. The filtrate was condensed under reduced pressure to afford the desired product (450 mg, 97.9%). (MS (ESI) m/z 341 [M+1]+.

Aufarbeitung

  1. filtrationfiltered through celite
  2. customcondensed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-ebef9d952b684c2ca9414dd62f5fef6f
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08372976B2

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