(4R,4aR,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;2,3-dihydroxybutanedioic acid → Hydrocodone

HRID 388179

Reaktionsgleichung

Reaktionsgleichung von HRID 388179
[CH3:1][N:2]1[C@@H:19]2[CH2:20][C:7]3[CH:8]=[CH:9][C:10]([O:21][CH3:22])=[C:11]4[O:12][C@H:13]5[C:14]([CH2:16][CH2:17][C@@H:18]2[C@:5]5([C:6]=34)[CH2:4][CH2:3]1)=[O:15].C(O)(C(O)=O)C(O)C(O)=O>O>[CH3:1][N:2]1[C@@H:19]2[CH2:20][C:7]3[CH:8]=[CH:9][C:10]([O:21][CH3:22])=[C:11]4[O:12][C@H:13]5[C:14]([CH2:16][CH2:17][C@@H:18]2[C@:5]5([C:6]=34)[CH2:4][CH2:3]1)=[O:15]

Komponenten

3

Edukt 1

HCID 20831824(4R,4aR,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;2,3-dihydroxybutanedioic acid

Produkt 1

HCID 5284569Hydrocodone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Hydrocodone polistirex was prepared by mixing 4.00 kg of hydrocodone bitartrate with 4.76 kg of ion-exchange resin particles (ABMERLITE IRP69; US Std. Mesh #100-#400) suspended in USP water at about 70° C. The resulting suspension was centrifuged and the product washed with USP water. The wet cake was dried and sieved through a US Std #30 mesh screen. The hydrocodone content of the dried product was equivalent to approximately 56% by weight of hydrocodone bitartrate.

Aufarbeitung

  1. washthe product washed with USP water
  2. customThe wet cake was dried
  3. filtrationsieved through a US Std #30 mesh screen

Quellen und Nachweise

ORD-Eintrag
ord-f2c0b9f44e33455e90132b83c01431cd
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08377480B2

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