1-(Benzyloxy)-2,5-difluoro-4-nitrobenzene → 4-Amino-2,5-difluorophenol

HRID 388514Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 388514
C([O:8][C:9]1[CH:14]=[C:13]([F:15])[C:12]([N+:16]([O-])=O)=[CH:11][C:10]=1[F:19])C1C=CC=CC=1>CO.[Pd]>[NH2:16][C:12]1[C:13]([F:15])=[CH:14][C:9]([OH:8])=[C:10]([F:19])[CH:11]=1

Komponenten

4

Edukt 1

HCID 574708681-(Benzyloxy)-2,5-difluoro-4-nitrobenzene

Produkt 1

HCID 27787624-Amino-2,5-difluorophenolAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 1-(benzyloxy)-2,5-difluoro-4-nitrobenzene (9.21 g) in methanol (300 ml) was added 10% palladium on carbon (921 mg), and the mixture was stirred at room temperature for 24 hours and 20 minutes under a hydrogen atmosphere. After terminating the reaction by substituting the atmosphere in the flask with nitrogen, the catalyst was filtered using Celite. The filtrate was distilled off under reduced pressure to give the title compound (4.96 g, 99%) as a brown solid.

Aufarbeitung

  1. customAfter terminating
  2. customthe reaction
  3. filtrationthe catalyst was filtered
  4. distillationThe filtrate was distilled off under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-9becd02f3430401c961afb6112be4201
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08377938B2

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