Thionyl Chloride → HCID 178508169, Verbindung

HRID 388617Notizen

Reaktionsgleichung

S(Cl)([Cl:3])=O.[NH2:5][C:6]1[C:15]2[N:16]=[C:17]([OH:24])[N:18]([CH2:19][CH2:20][CH2:21][CH2:22]O)[C:14]=2[C:13]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[N:7]=1>ClCCCl>[NH2:5][C:6]1[C:15]2[N:16]=[C:17]([OH:24])[N:18]([CH2:19][CH2:20][CH2:21][CH2:22][Cl:3])[C:14]=2[C:13]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[N:7]=1

Komponenten

Reaktionsbedingungen

Temperatur: 50 °C

Versuchsvorschrift

Thionyl chloride (1.1 mL, 15 mmol) was added to a solution of 4-amino-1-(4-hydroxybutyl)-1H-imidazo[4,5-c]quinolin-2-ol (3.5 g, 13 mmol) in 1,2-dichloroethane (60 mL), and the reaction was stirred at 50° C. overnight. A solid was present, which was collected by filtration and washed with diethyl ether (500 to 600 mL) to provide 3.24 g of 4-amino-1-(4-chlorobutyl)-1H-imidazo[4,5-c]quinolin-2-ol as a light gray solid.

Aufarbeitung

filtrationwhich was collected by filtration
washwashed with diethyl ether (500 to 600 mL)

Quellen und Nachweise

ORD-Eintrag: ord-7ed98ceceae343b9ae3316eb44a657af
Quelldatensatz: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08377957B2

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