Hydrochloric Acid → Ethyl 3-ethoxy-3-iminopropionate hydrochloride

HRID 389203

Reaktionsgleichung

[C:1]([CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5])#[N:2].[CH3:9][CH2:10][OH:11].[ClH:12]>CCOCC>[ClH:12].[CH2:10]([O:11][C:1](=[NH:2])[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5])[CH3:9]

Komponenten

Reaktionsbedingungen

Temperatur: 22 °C

Versuchsvorschrift

A stirred solution of ethyl cyanoacetate (30 mL, 281 mmol) and EtOH (18.1 mL, 278 mmol) in anhydrous Et2O (28.1 mL), at 0° C., was bubbled with HCl gas until saturated. The reaction was stirred at 22° C. for 20 hours and then concentrated to give the title product. 1H NMR (400 MHz, CDCl3) δ 4.73 (q, J=7.1 Hz, 2H); 4.24 (q, J=7.2 Hz, 2H); 3.89 (s, 2H); 1.51 (t, J=7.0 Hz, 3H); 1.30 (t, J=7.2 Hz, 3H) ppm.

Aufarbeitung

concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag: ord-b08448825301452abdc32df248ebf72f
Quelldatensatz: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08377874B2

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