4-Toluenesulfonyl chloride → HCID 59287022, Verbindung

HRID 389210Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 389210
[Br:1][C:2]1[CH:3]=[N+:4]([O-])[C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([O:12][CH3:13])[CH:6]=2.S(Cl)(C1C=CC(C)=CC=1)(=O)=[O:16]>CCOC(C)=O.C([O-])([O-])=O.[K+].[K+]>[Br:1][C:2]1[C:3](=[O:16])[NH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([O:12][CH3:13])[CH:6]=2

Komponenten

5

Edukt 2

HCID 73974-Toluenesulfonyl chlorideHCID 592871093-Bromo-7-methoxyquinoline 1-oxide

Produkt 1

HCID 59287022HCID 59287022, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8857Ethyl AcetateLösungsmittelHCID 11430Potassium CarbonateLösungsmittel

Versuchsvorschrift

To a solution of 3-bromo-7-methoxyquinoline 1-oxide (2.04 g, 8.03 mmol) in EtOAc (50 mL) and 15% aqueous K2CO3 (15 mL) at RT, TsCl (1.68 g, 8.83 mmol) was added. The reaction mixture was stirred vigorously at RT for 18 hours, at which time the product was collected by filtration and washed with EtOAc. The solid was dried under vacuum and used with no further purification. LRMS (M+H)+=254.1.

Aufarbeitung

  1. filtrationwas collected by filtration
  2. washwashed with EtOAc
  3. customThe solid was dried under vacuum
  4. customused with no further purification

Quellen und Nachweise

ORD-Eintrag
ord-02a1070da8bb4b269567a34eb3011c5a
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08377874B2

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