3-Methyl-2-butanone → 5-Methoxy-2,3,3-trimethyl-3H-indole

HRID 389239

Reaktionsgleichung

Reaktionsgleichung von HRID 389239
Cl.[CH3:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10]N)=[CH:6][CH:5]=1.[CH3:12][CH:13]([CH3:17])[C:14](=O)[CH3:15]>C(O)(=O)C>[CH3:2][O:3][C:4]1[CH:9]=[C:8]2[C:7](=[CH:6][CH:5]=1)[N:10]=[C:14]([CH3:15])[C:13]2([CH3:17])[CH3:12]

Komponenten

4

Edukt 2

HCID 112513-Methyl-2-butanoneHCID 27239044-Methoxyphenylhydrazine hydrochloride

Produkt 1

HCID 110953925-Methoxy-2,3,3-trimethyl-3H-indole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
10 °C

Versuchsvorschrift

To 4-methoxyphenyl hydrazine hydrochloride (4.84 g) was added 3-methyl-2-butanone (6.4 ml) and acetic acid (45 ml). The mixture was heated to 10° C. for 2.5 hours after which time the solvent was removed by rotary evaporation. Flash column chromatography gave the product (4.66 g).

Aufarbeitung

  1. customwas removed by rotary evaporation

Quellen und Nachweise

ORD-Eintrag
ord-0f58494c1ef14cdc90d2e0dcd78b2684
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08378120B2

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