Water → HCID 66812442, Verbindung

HRID 389298

Reaktionsgleichung

Reaktionsgleichung von HRID 389298
[OH:1][C:2]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[C:7]2[C:3]=1[CH2:4][CH2:5][CH2:6]2.C(=O)([O-])[O-].[K+].[K+].Br[CH2:20][C:21]([C:23]1[S:24][CH:25]=[CH:26][CH:27]=1)=[O:22].O>CC(C)=O>[CH3:12][O:11][C:8]1[CH:9]=[CH:10][C:2]([O:1][CH2:20][C:21]([C:23]2[S:24][CH:25]=[CH:26][CH:27]=2)=[O:22])=[C:3]2[C:7]=1[CH2:6][CH2:5][CH2:4]2

Komponenten

6

Edukt 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 27763722-Bromo-1-(thiophen-2-yl)ethan-1-oneHCID 206091567-Methoxy-2,3-dihydro-1H-inden-4-ol

Produkt 1

HCID 66812442HCID 66812442, VerbindungAusbeute 60,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel2×

Versuchsvorschrift

To the clear solution of 4-Hydroxy-7-methoxy indane (2.0 gm, 0.0121 mole) in Acetone (20 ml), Potassium carbonate (2.52 gm, 0.0182 mole) was added at room temperature and stirred for 1.5 hours. A solution of 2-Bromo-1-thiophene-2-yl-ethanone (3.75 gm, 0.0181 mole) in Acetone (10 ml) was added at 0° C. and stirred for 8 hours at room temperature. The reaction mixture was poured into the water (50 ml) and extracted with Ethyl acetate (2×100 ml). The Ethyl acetate layer was dried over Sodium sulphate and evaporated to give a crude product which was purified by column chromatography using 2% Ethyl acetate in hexane as a mobile phase The collected eluent was evaporated to yield desire product (2.1 gm) as an viscous oil.

Aufarbeitung

  1. stirringstirred for 8 hours at room temperature
  2. extractionextracted with Ethyl acetate (2×100 ml)
  3. dry with materialThe Ethyl acetate layer was dried over Sodium sulphate
  4. customevaporated
  5. customto give a crude product which
  6. customwas purified by column chromatography
  7. customwas evaporated

Quellen und Nachweise

ORD-Eintrag
ord-7f6be388d1fa4e69bc198ba02de6f0f4
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08378118B2

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