Toluene → 1-(2-Amino-5-chlorophenyl)-2,2,2-trifluoroethanone

HRID 389400

Reaktionsgleichung

Reaktionsgleichung von HRID 389400
O.Cl.[NH2:3][C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:5]=1[C:11](=[O:16])[C:12]([F:15])([F:14])[F:13].C1(C)C=CC=CC=1.C([O-])(O)=O.[Na+]>O>[NH2:3][C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:5]=1[C:11](=[O:16])[C:12]([F:15])([F:13])[F:14]

Komponenten

5

Edukt 3

HCID 1140TolueneHCID 516892Sodium BicarbonateHCID 441819891-(2-Amino-5-chlorophenyl)-2,2,2-trifluoroethan-1-one--hydrogen chloride--water (1/1/1)

Produkt 1

HCID 109878821-(2-Amino-5-chlorophenyl)-2,2,2-trifluoroethanoneAusbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 1-(2-amino-5-chlorophenyl)-2,2,2-trifluoroethanone hydrochloride hydrate (48.5 g, 174.4 mmol), 300 mL toluene, and 150 mL water was stirred at room temperature for 30 minutes. The pH of the solution was adjusted to 7-8 via the addition of saturated aqueous NaHCO3 solution. The resulting mixture was then separated, and the toluene layer was collected and evaporated to dryness to give 38.2 g 1-(2-amino-5-chlorophenyl)-2,2,2-trifluoroethanone (2) as a yellow solid.

Aufarbeitung

  1. customThe resulting mixture was then separated
  2. customthe toluene layer was collected
  3. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-fada4446c00c49f2901602a3feaaa21c
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08378143B2

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