2,6-Difluorobenzoic acid → Sodium 2,6-difluorobenzoate

HRID 389696Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 389696
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([OH:6])=[O:5].[OH-].[Na+:13]>CCO.O>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([O-:6])=[O:5].[Na+:13]

Komponenten

5

Edukt 2

HCID 97962,6-Difluorobenzoic acidHCID 14798Sodium Hydroxide

Produkt 1

HCID 23698872Sodium 2,6-difluorobenzoateAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

To a solution of 2,6-difluorobenzoic acid (1.00 g, 6.3 mmol) in EtOH and water (5:1, 60 mL) was added 1N aqueous sodium hydroxide solution (6.33 mL, 6.3 mmol). The reaction mixture was stirred for 10 minutes at room temperature and then solvents were removed in vacuo to yield sodium 2,6-difluorobenzoate (1.22 g, 6.3 mmol, quantitative) as an off white solid. 1H NMR (DMSO) δ 6.89 (2H, m), 7.15 (1H, m).

Aufarbeitung

  1. customsolvents were removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-3bb7b79af1a34891b64d1777f159f6db
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08378095B2

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