Water → 4-(2-Hydroxyacetyl)benzonitrile

HRID 389880Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 389880
Br[CH2:2][C:3]([C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[CH:7][CH:6]=1)=[O:4].[OH2:13]>C(#N)C>[OH:13][CH2:2][C:3]([C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[CH:7][CH:6]=1)=[O:4]

Komponenten

4

Edukt 2

HCID 962WaterHCID 986544-(Bromoacetyl)benzonitrile

Produkt 1

HCID 179928864-(2-Hydroxyacetyl)benzonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A solution of 1 g of 4-(2-bromoacetyl)benzonitrile in acetonitrile (5 mL) and water (10 mL) is treated under microwave irradiation (125° C., 50 min). The same experiment is conducted five times. All the vials are collected, extracted with ethyl ether, dried over magnesium sulfate and concentrated under vacuum to give the desired compound.

Aufarbeitung

  1. customAll the vials are collected
  2. extractionextracted with ethyl ether
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-103dc8cfdc194c609774dca0383cc9eb
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08383608B2

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