Water → 2-Hydroxy-3'-(trifluoromethyl)acetophenone

HRID 389890Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 389890
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]([F:14])([F:13])[F:12])[CH:6]=1)=[O:4].[OH2:15]>C(#N)C>[F:12][C:11]([F:14])([F:13])[C:7]1[CH:6]=[C:5]([C:3](=[O:4])[CH2:2][OH:15])[CH:10]=[CH:9][CH:8]=1

Komponenten

4

Edukt 2

HCID 962WaterHCID 27783862-Bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-one

Produkt 1

HCID 167269582-Hydroxy-3'-(trifluoromethyl)acetophenone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A solution of 2-bromo-1-[3-(trifluoromethyl)phenyl]ethanone (1 g) in acetonitrile (2.5 mL) and water (10 mL) is treated under microwave irradiation (125° C., 50 min). The same experiment is repeated five times. All the vials are collected, extracted with DCM, dried over magnesium sulfate and concentrated under vacuum to give the desired compound.

Aufarbeitung

  1. customAll the vials are collected
  2. extractionextracted with DCM
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-ba55c46c5d4f44f2a5e9f3d295235304
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08383608B2

Notizen zur Reaktion

Wird geladen…