Water → 2-Hydroxy-1-(3-methylphenyl)ethan-1-one

HRID 389896

Reaktionsgleichung

Reaktionsgleichung von HRID 389896
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[CH:6]=1)=[O:4].[OH2:12]>C(#N)C>[OH:12][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[CH:6]=1)=[O:4]

Komponenten

4

Edukt 2

HCID 962WaterHCID 100361292-Bromo-1-(3-methylphenyl)ethan-1-one

Produkt 1

HCID 183729052-Hydroxy-1-(3-methylphenyl)ethan-1-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A solution of 2-bromo-1-(3-methylphenyl)ethanone (1 g) in acetonitrile (2.5 mL) and water (13 mL) is treated under microwave irradiation (125° C., 50 min). The same experiment is repeated three times. All the vials are collected, extracted with DCM, dried over magnesium sulfate and concentrated under vacuum to give the desired compound.

Aufarbeitung

  1. customAll the vials are collected
  2. extractionextracted with DCM
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-53b1fb3a11334045a8e1fdc82626b016
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08383608B2

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