Benzylamine → 4-(Benzylamino)butanenitrile

HRID 389999Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 389999
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[Ca+2]>C(#N)C>[CH2:1]([NH:8][CH2:4][CH2:3][CH2:2][C:1]#[N:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 7504BenzylamineHCID 10112Calcium Carbonate

Produkt 1

HCID 30145704-(Benzylamino)butanenitrileAusbeute 166,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

Benzylamine (5.02 mL, 46 mmol) and calcium carbonate (23.65 g, 171.12 mmol) dissolved in anhydrous acetonitrile (115 mL) were stirred for 10 minutes at room temperature. After adding 4-bromonitrile (4.78 mL, 48.3 mmol), reaction was carried out at 100° C. for 2 days. A target compound (6.69 g, 38.395 mmol, 83.5%) was yielded as liquid by separating the reaction mixture in the same manner as Reference Example 1.

Aufarbeitung

  1. additionAfter adding
  2. waitwas carried out at 100° C. for 2 days

Quellen und Nachweise

ORD-Eintrag
ord-11754a33812a49c4ad8c502369587f9a
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08383631B2

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