Ammonia → 3-(5-Fluoropyridin-3-yl)-5-(3-(trifluoromethyl)phenyl)isoxazole
Reaktionsgleichung
[F:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:11]=1)[C:7](Cl)=[N:8][OH:9].[C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[CH:15]=1)#[CH:13].N>>[F:1][C:2]1[CH:11]=[C:6]([C:7]2[CH:13]=[C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:21])([F:22])[F:23])[CH:15]=3)[O:9][N:8]=2)[CH:5]=[N:4][CH:3]=1Komponenten
4
Versuchsvorschrift
The titled compound was prepared according to Method CB using the product of Example 28B (88 mg, 0.5 mmol) and 1-ethynyl-3-(trifluoromethyl)benzene (Aldrich, 85 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) δ 7.57 (s, 1H), 7.71-7.96 (m, 2H), 8.09-8.32 (m, 3H), 8.62 (d, J=2.7 Hz, 1H), 8.98 (t, J=1.5 Hz, 1H) ppm; MS (DCI/NH3) m/z 309 (M+H)+.