4-Chloro-6-(chloromethyl)pyrimidin-2-amine → 2-Amino-4-chloro-6-chloromethyl-pyrimidine hydrochloride

HRID 3915

Reaktionsgleichung

Reaktionsgleichung von HRID 3915
[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4]([CH2:9][Cl:10])[N:3]=1>C(OCC)C.Cl>[ClH:8].[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4]([CH2:9][Cl:10])[N:3]=1

Komponenten

4

Edukt 1

HCID 201534884-Chloro-6-(chloromethyl)pyrimidin-2-amine

Produkt 1

HCID 201535002-Amino-4-chloro-6-chloromethyl-pyrimidine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

3.56 Parts of 2-amino-4-chloro-6-chloromethylpyrimidine was dissolved in 53 parts of dry diethyl ether and dry hydrogen chloride was bubbled through the solution, with stirring, until no further solid precipitated the solid was filtered, washed with ether and dried in vacuo. Recrystallisation from acetone gave 2-amino-4-chloro-6-chloromethyl-pyrimidine hydrochloride m.p. 145°-150° C. (decomposition).

Aufarbeitung

  1. customwas bubbled through the solution
  2. customprecipitated the solid
  3. filtrationwas filtered
  4. washwashed with ether
  5. customdried in vacuo
  6. customRecrystallisation from acetone

Quellen und Nachweise

ORD-Eintrag
ord-58de8242ae774164a8154c623f6db4b7
Quelldatensatz
uspto-grants-1988_02
Patentnummer
US04723006

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