4-Nitroacetanilide → 4-Aminoacetanilide

HRID 392027

Reaktionsgleichung

Reaktionsgleichung von HRID 392027
[NH:1]([C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-])=O)=[CH:7][CH:6]=1)[C:2]([CH3:4])=[O:3].O.NN>CO.[Ni]>[NH:1]([C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][CH:6]=1)[C:2]([CH3:4])=[O:3]

Komponenten

5

Edukt 2

HCID 76914-NitroacetanilideHCID 24654Hydrazine hydrate (1:1)

Produkt 1

HCID 312304-Aminoacetanilide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

1.688 g (9.38 mmol) p-acetamino nitrobenzene is dissolved in 10 ml of anhydrous methanol. Suitable amount, i.e., 0.1266 g Raney-Ni and 0.83 g (14.1 mmol, 85%) hydrazine hydrate is added to the solution. The mixture is reacted for 6 hours, and then suction filtered. The filtrate is concentrated to give a product, p-acetamino aniline. The yield reaches the theoretical value.

Aufarbeitung

  1. customThe mixture is reacted for 6 hours
  2. filtrationsuction filtered
  3. concentrationThe filtrate is concentrated

Quellen und Nachweise

ORD-Eintrag
ord-7b5bee5ffd22411b9c225814c72c5636
Quelldatensatz
uspto-grants-2004_10
Patentnummer
US06800590B2

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