2,2-dimethoxyethyl N-benzyloxycarbonylglycine → 2,2-Dimethoxyethyl glycine

To a solution of compound 37 (425 mg, 1.43 mmol) dissolved in 20 mL of anhydrous THF in a Parr apparatus for hydrogenation, was added 160 mg of 10% Pd/C, the system was charged with 60 psi of H2, and the bottle was shaken for 2 h. The catalyst was filtered over Celite, washed with 20 mL of ethyl acetate and the combined filtrate was concentrated in vacuo to give 38 (180 mg, 77%). 1H NMR (400 MHz, CDCl3) δ 3.36 (s, 6H), 3.42 (s, 2H), 4.08 (d, J=5.3 Hz, 2H), 4.54 (t, J=5.3 Hz, 1H).

1. additionthe system was charged with 60 psi of H2
2. filtrationThe catalyst was filtered over Celite
3. washwashed with 20 mL of ethyl acetate
4. concentrationthe combined filtrate was concentrated in vacuo

ORD-Eintrag

ord-3fb39e9d7c8241268885ef176626c218

Quelldatensatz

uspto-grants-2013_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08524691B2