Formic Acid → HCID 178487492, Verbindung

HRID 392580

Reaktionsgleichung

Reaktionsgleichung von HRID 392580
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([C:13]([C:15]1[N:16]=[CH:17][N:18](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[CH:19]=1)=[O:14])[CH:7]=[CH:6]2.C(O)=O.[CH2:42]1[CH2:46]OC[CH2:43]1>>[NH:18]1[CH:19]=[C:15]([C:13]([C:8]2[CH:7]=[CH:6][C:5]3[C:10](=[CH:11][CH:12]=[C:3]([O:2][CH3:1])[CH:4]=3)[CH:9]=2)([OH:14])[CH:42]([CH3:46])[CH3:43])[N:16]=[CH:17]1

Komponenten

4

Edukt 3

HCID 284Formic AcidHCID 8028TetrahydrofuranHCID 11733735(6-Methoxynaphthalen-2-yl)-(1-trityl-1H-imidazol-4-yl)ketone

Produkt 1

HCID 178487492HCID 178487492, Verbindung

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

(6-Methoxynaphthalen-2-yl)-(1-trityl-1H-imidazol-4-yl)ketone (15.0 g) was dissolved in THF (80 ml) and 90% formic acid (20 ml) was added. The mixture was stirred at 50° C. for 2 h and the solvent was evaporated. 1N Hydrochloric acid (60 ml) was added and the precipitate was filtrated. The filtrate was washed with ether and neutralized with potassium carbonate. The resulting precipitate was collected by filtration and dried under reduced pressure to give the title compound (7.54 g) as a colorless solid.

Aufarbeitung

  1. customthe solvent was evaporated
  2. addition1N Hydrochloric acid (60 ml) was added
  3. filtrationthe precipitate was filtrated
  4. washThe filtrate was washed with ether and neutralized with potassium carbonate
  5. filtrationThe resulting precipitate was collected by filtration
  6. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-acd1013aaac349c5bb3de64a8bc69a98
Quelldatensatz
uspto-grants-2004_10
Patentnummer
US06800778B1

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