Piperidine → Phe-Gly
Reaktionsgleichung
C1C2C(COC([NH:18][C@H:19]([C:27]([NH:29][CH2:30][C:31]([OH:33])=[O:32])=[O:28])[CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=O)C3C(=CC=CC=3)C=2C=CC=1.N1CCCCC1>CN(C=O)C>[NH2:18][C@H:19]([C:27]([NH:29][CH2:30][C:31]([OH:33])=[O:32])=[O:28])[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1Komponenten
4
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Fmoc-protected dipeptide 72 (500 mg, 1.00 mmol) was treated with a 5% v/v solution of piperidine in DMF (5 mL). After stirring for 1 h, the reaction mixture was concentrated to dryness. The crude material was used for the next step without purification.
Aufarbeitung
- concentrationthe reaction mixture was concentrated to dryness
- customThe crude material was used for the next step without purification
Quellen und Nachweise
- ORD-Eintrag
- ord-f2ae1b8090a940d2913985de4b8df854
- Quelldatensatz
- uspto-grants-2013_09
- Patentnummer
- US08524691B2
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