Piperidine → Glycyl-phenylalanyl-glycine

HRID 39265

Reaktionsgleichung

Reaktionsgleichung von HRID 39265
C1C2C(COC([NH:18][CH2:19][C:20]([NH:22][C@H:23]([C:31]([NH:33][CH2:34][C:35]([OH:37])=[O:36])=[O:32])[CH2:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[O:21])=O)C3C(=CC=CC=3)C=2C=CC=1.N1CCCCC1>CN(C=O)C>[NH2:18][CH2:19][C:20]([NH:22][C@H:23]([C:31]([NH:33][CH2:34][C:35]([OH:37])=[O:36])=[O:32])[CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[O:21]

Komponenten

4

Edukt 2

HCID 8082PiperidineHCID 15222489N-Fmoc-glycyl-L-phenylalanyl-glycine

Produkt 1

HCID 6992441Glycyl-phenylalanyl-glycine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

Fmoc-protected tripeptide 74 (546 mg, 0.98 mmol) was treated with a 5% v/v solution of piperidine in DMF (5 mL). After stirring for 45 min, the reaction mixture was concentrated to dryness. The crude material was used for the next step without purification.

Aufarbeitung

  1. concentrationthe reaction mixture was concentrated to dryness
  2. customThe crude material was used for the next step without purification

Quellen und Nachweise

ORD-Eintrag
ord-7e66b13904154ebcbe524b75757fe2f1
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08524691B2

Verknüpfte Notizen

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