Sodium Hydroxide → tert-butyl (3S)-3-(hydroxymethyl)piperazine-1-carboxylate

HRID 392678Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 392678
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][NH:11][C@H:10]([C:14](OC)=[O:15])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+].S([O-])([O-])(=O)=O.[Na+].[Na+]>O1CCCC1.ClCCl>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][NH:11][C@H:10]([CH2:14][OH:15])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Komponenten

7

Edukt 4

HCID 14798Sodium HydroxideHCID 24436Sodium SulfateHCID 15018551-tert-butyl 3-methyl (3S)-piperazine-1,3-dicarboxylateHCID 21226445Aluminium lithium hydride

Produkt 1

HCID 24820294tert-butyl (3S)-3-(hydroxymethyl)piperazine-1-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

A solution of Example 1 (c) in dry tetrahydrofuran (40 ml) at 0° C. was treated with lithium aluminum hydride (0.50 g) and the mixture was stirred at 0° C. for 1.5 hours. The cooled solution was treated dropwise with a solution of 2M sodium hydroxide until a white precipitate had formed. Dichloromethane and anhydrous sodium sulfate were added and the solution was filtered and evaporated to give a pale yellow oil (3.0 g).

Aufarbeitung

  1. customhad formed
  2. filtrationthe solution was filtered
  3. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-58b28852f18f4c3bb996c6534bab0abb
Quelldatensatz
uspto-grants-2004_10
Patentnummer
US06803369B1

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