Acetyl chloride → N-biphenyl-3-ylmethyl-acetamide

HRID 392830

Reaktionsgleichung

Reaktionsgleichung von HRID 392830
[C:1]1([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][NH2:8])[CH:2]=1.C([O-])(O)=O.[Na+].[C:20](Cl)(=[O:22])[CH3:21]>C(Cl)Cl>[C:1]1([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][NH:8][C:20](=[O:22])[CH3:21])[CH:2]=1

Komponenten

5

Edukt 3

HCID 6367Acetyl chlorideHCID 516892Sodium BicarbonateHCID 27603683-(Aminomethyl)biphenyl

Produkt 1

HCID 22660935N-biphenyl-3-ylmethyl-acetamideAusbeute 128,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

C-Biphenyl-3-yl-methylamine (700 mg, 3.8 mmol) was dissolved in 38 mL of CH2Cl2. To this was added 38 mL of satd NaHCO3 (aq) followed by acetyl chloride (1.41 mL 19,8 mmol). The resulting mixture was stirred 45 min. The organic layer was separated, washed with satd NaCl, dried over Na2SO4, filtered and solvent removed under vacuum to yield 1.1 grams of N-biphenyl-3-ylmethyl-acetamide.

Aufarbeitung

  1. customThe organic layer was separated
  2. washwashed with satd NaCl
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. customsolvent removed under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-dedfeb76dab54b4b9c853a25bd0c6433
Quelldatensatz
uspto-grants-2004_10
Patentnummer
US06803378B2

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