Tert-butyl 4-[hydroxy(4-methoxy-3-isopropylphenyl)methyl]-3,5-dimethylphenylcarbamate → HCID 15552186, Verbindung

HRID 392887Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 392887
O[CH:2]([C:19]1[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[C:21]([CH:27]([CH3:29])[CH3:28])[CH:20]=1)[C:3]1[C:8]([CH3:9])=[CH:7][C:6]([NH:10][C:11](=[O:17])[O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[CH:5][C:4]=1[CH3:18].[H][H]>[Pd]>[CH3:26][O:25][C:22]1[CH:23]=[CH:24][C:19]([CH2:2][C:3]2[C:4]([CH3:18])=[CH:5][C:6]([NH:10][C:11](=[O:17])[O:12][C:13]([CH3:14])([CH3:15])[CH3:16])=[CH:7][C:8]=2[CH3:9])=[CH:20][C:21]=1[CH:27]([CH3:29])[CH3:28]

Komponenten

4

Edukt 2

HCID 22662124Tert-butyl 4-[hydroxy(4-methoxy-3-isopropylphenyl)methyl]-3,5-dimethylphenylcarbamateHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 15552186HCID 15552186, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23938PalladiumKatalysator

Versuchsvorschrift

730 mg (1.66 mmol) of tert-butyl 4-[hydroxy(4-methoxy-3-isopropylphenyl)methyl]-3,5-dimethylphenylcarbamate (Example V) are hydrogenated with 700 mg of Pd/C (10%) and with 1 bar of hydrogen at RT for 4 hours. The mixture is filtered through kieselguhr, the solvent is removed in vacuo, and purification by chromatography results in 578 mg (91%) of tert-butyl 4-(4-methoxy-3-isopropylbenzyl)-3,5-dimethylphenylcarbamate.

Aufarbeitung

  1. filtrationThe mixture is filtered through kieselguhr
  2. customthe solvent is removed in vacuo, and purification by chromatography
  3. customresults in 578 mg (91%) of tert-butyl 4-(4-methoxy-3-isopropylbenzyl)-3,5-dimethylphenylcarbamate

Quellen und Nachweise

ORD-Eintrag
ord-278f3dd0fdf54b249372c999d536c985
Quelldatensatz
uspto-grants-2004_10
Patentnummer
US06803480B2

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