Di-tert-butyl dicarbonate → 3-(N,N-dimethylcarbamoyl)-2,6-dimethylphenylisocyanate

HRID 393233

Reaktionsgleichung

Reaktionsgleichung von HRID 393233
[C:1](OC(OC(C)(C)C)=O)(OC(C)(C)C)=[O:2].[NH2:16][C:17]1[C:18]([CH3:29])=[C:19]([CH:25]=[CH:26][C:27]=1[CH3:28])[C:20]([N:22]([CH3:24])[CH3:23])=[O:21].C(N(CC)C1C=CN=CC=1)C>C(Cl)Cl>[CH3:23][N:22]([CH3:24])[C:20]([C:19]1[C:18]([CH3:29])=[C:17]([N:16]=[C:1]=[O:2])[C:27]([CH3:28])=[CH:26][CH:25]=1)=[O:21]

Komponenten

5

Edukt 3

HCID 90495Di-tert-butyl dicarbonateHCID 35555903-amino-N,N,2,4-tetramethylbenzamideHCID 117687514-Diethylaminopyridine

Produkt 1

HCID 226492453-(N,N-dimethylcarbamoyl)-2,6-dimethylphenylisocyanate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel3×

Versuchsvorschrift

A solution of di-tert-butyl dicarbonate (0.081 g) in methylene chloride (1.6 ml) and a solution of 3-amino-N,N,2,4-tetramethylbenzamide (J. Chem. Soc., Perkin Trans, I. 1973, 1-4; 0.072 g) in methylene chloride (1.0 ml) were added in turn to a solution of 4-diethylaminopyridine (0.004 g) in methylene chloride (0.4 ml). The resultant mixture was stirred at ambient temperature for 20 minutes. There was thus obtained a solution of 3-(N,N-dimethylcarbamoyl)-2,6-dimethylphenylisocyanate which was used without further purification.

Quellen und Nachweise

ORD-Eintrag
ord-90e63403a3b04e14a580e24b09a56348
Quelldatensatz
uspto-grants-2004_10
Patentnummer
US06806274B1

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