Formic Acid → HCID 136388388, Verbindung

HRID 393245Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 393245
[NH2:1][C:2]1[C:11]([C:12](=[O:14])[NH2:13])=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([OH:15])[CH:3]=1.[CH:16](O)=O>>[OH:15][C:4]1[CH:3]=[C:2]2[C:11]([C:12](=[O:14])[NH:13][CH:16]=[N:1]2)=[CH:10][C:5]=1[C:6]([O:8][CH3:9])=[O:7]

Komponenten

3

Edukt 2

HCID 284Formic AcidHCID 22649192HCID 22649192, Verbindung

Produkt 1

HCID 136388388HCID 136388388, Verbindung

Versuchsvorschrift

A mixture of methyl 4-amino-5-carbamoyl-2-hydroxybenzoate (5.4 g) and formic acid (50 ml) was heated to reflux for 1 hour. The mixture was evaporated. Toluene (75 ml) was added and the mixture was evaporated. The solid residue was washed with methanol and diethyl ether and dried to give methyl 7-hydroxy-4-oxo-3,4-dihydroquinazolin-6-carboxylate (5.2 g); NMR Spectrum: (DMSOd6) 4.9 (s, 3H), 7.09 (s, 1H), 7.39 (s, 1H), 8.5 (s, 1H).

Aufarbeitung

  1. temperaturewas heated
  2. temperatureto reflux for 1 hour
  3. customThe mixture was evaporated
  4. additionToluene (75 ml) was added
  5. customthe mixture was evaporated
  6. washThe solid residue was washed with methanol and diethyl ether
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-850cabeb028b4b338e7ad34e2df0c418
Quelldatensatz
uspto-grants-2004_10
Patentnummer
US06806274B1

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