(4-Nitrophenyl)acetic acid → Benzeneacetyl chloride, 4-nitro-

HRID 393848

Reaktionsgleichung

Reaktionsgleichung von HRID 393848
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[N+:7]([C:10]1[CH:15]=[CH:14][C:13](CC(O)=O)=[CH:12][CH:11]=1)([O-:9])=[O:8].CN(C=O)C>ClCCl>[N+:7]([C:10]1[CH:15]=[CH:14][C:13]([CH2:1][C:2]([Cl:4])=[O:3])=[CH:12][CH:11]=1)([O-:9])=[O:8]

Komponenten

5

Edukt 3

HCID 4661(4-Nitrophenyl)acetic acidHCID 6228DimethylformamideHCID 65578Oxalyl chloride

Produkt 1

HCID 6452210Benzeneacetyl chloride, 4-nitro-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

3.75 ml (7.5 mmoles) of a 2M solution of oxalyl chloride in dichloromethane is added at 20° C. to a solution of 0.9 g (5 mmoles) of 4-nitrophenylacetic acid in a mixture composed of 10 ml of dichloromethane and 0.5 ml of DMF. After agitation for 30 minutes, the solution is concentrated under vacuum. The yellow oil obtained is used without additional purification in the following stage.

Aufarbeitung

  1. concentrationthe solution is concentrated under vacuum
  2. customThe yellow oil obtained
  3. customis used without additional purification in the following stage

Quellen und Nachweise

ORD-Eintrag
ord-a2c4d1ad5c0049ed90be11c40f056869
Quelldatensatz
uspto-grants-2004_10
Patentnummer
US06809088B2

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