Lithium Hydroxide → (2S)-2-ethoxy-3-{2-methyl-4-[2-(4-trifluoromethyl-phenyl)-thiazol-4-ylmethoxy]-phenyl}-propionic acid

HRID 394252Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 394252
C[O:2][C:3](=[O:33])[C@@H:4]([O:30][CH2:31][CH3:32])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][C:14]2[N:15]=[C:16]([C:19]3[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=3)[S:17][CH:18]=2)=[CH:8][C:7]=1[CH3:29].[Li+].[OH-]>>[CH2:31]([O:30][C@@H:4]([CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][C:14]2[N:15]=[C:16]([C:19]3[CH:20]=[CH:21][C:22]([C:25]([F:26])([F:27])[F:28])=[CH:23][CH:24]=3)[S:17][CH:18]=2)=[CH:8][C:7]=1[CH3:29])[C:3]([OH:33])=[O:2])[CH3:32]

Komponenten

3

Edukt 2

HCID 3939Lithium HydroxideHCID 68617708(2S)-2-ethoxy-3-{2-methyl-4-[2-(4-trifluoromethyl-phenyl)-thiazol-4-ylmethoxy]-phenyl}-propionic acid methyl ester

Produkt 1

HCID 68617862(2S)-2-ethoxy-3-{2-methyl-4-[2-(4-trifluoromethyl-phenyl)-thiazol-4-ylmethoxy]-phenyl}-propionic acid

Versuchsvorschrift

In analogy to the procedure described in example 10 d], (2S)-2-ethoxy-3-{2-methyl-4-[2-(4-trifluoromethyl-phenyl)-thiazol-4-ylmethoxy]-phenyl}-propionic acid methyl ester was treated with LiOH to obtain (2S)-2-ethoxy-3-{2-methyl-4-[2-(4-trifluoromethyl-phenyl)-thiazol-4-ylmethoxy]-phenyl}-propionic acid as colorless solid.

Aufarbeitung

  1. customdescribed in example 10 d

Quellen und Nachweise

ORD-Eintrag
ord-646a013d85f04d54bbbf3b1e00034d0c
Quelldatensatz
uspto-grants-2004_10
Patentnummer
US06809110B2

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