Hydrochloric Acid → 2-Cyclopropyl-4,6-bis-trifluoromethyl-benzaldehyde

HRID 39429

Reaktionsgleichung

Reaktionsgleichung von HRID 39429
C(N=[CH:6][C:7]1[C:12]([C:13]([F:16])([F:15])[F:14])=[CH:11][C:10]([C:17]([F:20])([F:19])[F:18])=[CH:9][C:8]=1[CH:21]1[CH2:23][CH2:22]1)CCC.Cl.[OH2:25]>>[CH:21]1([C:8]2[CH:9]=[C:10]([C:17]([F:20])([F:19])[F:18])[CH:11]=[C:12]([C:13]([F:16])([F:15])[F:14])[C:7]=2[CH:6]=[O:25])[CH2:23][CH2:22]1

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 58167766Butyl-[1-(2-cyclopropyl-4,6-bis-trifluoromethyl-phenyl)-methylidene]-amine2×

Produkt 1

HCID 581677622-Cyclopropyl-4,6-bis-trifluoromethyl-benzaldehyde

Versuchsvorschrift

Crude butyl-[1-(2-cyclopropyl-4,6-bis-trifluoromethyl-phenyl)-methylidene]-amine (intermediate M, 3.54 g, 10.5 mmol) was dissolved in 8 mL water. Hydrochloric acid (25%, 0.49 mL) was added and the mixture was refluxed for 2 h. The mixture was extracted three times with ethyl acetate. The combined organic phases were dried on sodium sulfate, filtered and evaporated. The crude material, brown oil (1.01 g, 34%) was used without further purification.

Aufarbeitung

  1. temperaturethe mixture was refluxed for 2 h
  2. extractionThe mixture was extracted three times with ethyl acetate
  3. customThe combined organic phases were dried on sodium sulfate
  4. filtrationfiltered
  5. customevaporated
  6. customThe crude material, brown oil (1.01 g, 34%) was used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-0fd61689e9a54fc3b695b3fe7ef68bd7
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08524909B2

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