Bromine → 2-Bromo-1-(4-hydroxy-2-methylphenyl)ethanone

HRID 394883

Reaktionsgleichung

Reaktionsgleichung von HRID 394883
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[C:4]([CH3:11])[CH:3]=1.[Br:12]Br>O1CCOCC1>[Br:12][CH2:9][C:8]([C:5]1[CH:6]=[CH:7][C:2]([OH:1])=[CH:3][C:4]=1[CH3:11])=[O:10]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 701334-Hydroxy-2-methylacetophenone

Produkt 1

HCID 178121702-Bromo-1-(4-hydroxy-2-methylphenyl)ethanoneAusbeute 81 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel2×

Versuchsvorschrift

To a stirred solution of 4′-hydroxy-2′-methylacetophenone (4.5 g, 30.0 mmol) in dioxane (7 ml) was added a solution of bromine (4.87 g, 30.5 mmol) in dioxane (28 ml) dropwise at room temperature. After addition, the mixture was stirred at room temperature for 30 minutes. The volatile was evaporated in vacuo, and the residue was used for next reaction without further purification. (5.57 g, 81% yield).

Aufarbeitung

  1. additionAfter addition
  2. customThe volatile was evaporated in vacuo
  3. customthe residue was used for next reaction without further purification

Quellen und Nachweise

ORD-Eintrag
ord-c9930b85b2304d91879edd2c1c740489
Quelldatensatz
uspto-grants-2003_08
Patentnummer
US06603008B1

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