Sodium borohydride → HCID 23003647, Verbindung

HRID 396338Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 396338
[BH4-].[Na+].[CH2:3]([N:10]1[CH2:15][CH:14]([CH2:16][CH3:17])[C:13](=[O:18])[C:12]([CH2:20][CH3:21])([CH3:19])[CH2:11]1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>CO>[CH2:3]([N:10]1[CH2:15][CH:14]([CH2:16][CH3:17])[CH:13]([OH:18])[C:12]([CH2:20][CH3:21])([CH3:19])[CH2:11]1)[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

Komponenten

4

Edukt 2

HCID 4311764Sodium borohydrideHCID 222788783,5-Diethyl-3-methyl-1-(phenylmethyl)-4-piperidinone

Produkt 1

HCID 23003647HCID 23003647, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Sodium borohydride (0.18 g, 4.8 mmole) was added to the stirred solution of 1-benzyl-3,5-diethyl-3-methylpiperidin-4-one (2.0 g, 7.72 mmole) in methanol (20 ml) at 0-5° C. over a period of 5 min, and stirring was continued for 1 hr at ambient temperature. The reaction mixture was concentrated to dryness, triturated with water (20 ml) and extracted with ethyl acetate. The ethyl acetate extract was dried (Na2SO4) and concentrated to dryness to furnish 1-benzyl-3,5-diethyl-4-hydroxy-3-methylpiperidine as oil. Yield 1.8 g (89%), C17H27NO, m/z 262 (M+l).

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated to dryness
  2. customtriturated with water (20 ml)
  3. extractionextracted with ethyl acetate
  4. extractionThe ethyl acetate extract
  5. dry with materialwas dried (Na2SO4)
  6. concentrationconcentrated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-c82c1ff15c98495c9ae641759fe7f02d
Quelldatensatz
uspto-grants-2003_08
Patentnummer
US06608078B2

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