Oxalyl chloride → 2-(2-furyl)quinoline-4-carbonyl Chloride

HRID 396344Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 396344
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[O:7]1[CH:11]=[CH:10][CH:9]=[C:8]1[C:12]1[CH:21]=C(C(O)=O)[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]=1>C(Cl)Cl>[O:7]1[CH:11]=[CH:10][CH:9]=[C:8]1[C:12]1[CH:21]=[C:1]([C:2]([Cl:4])=[O:3])[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]=1

Komponenten

4

Edukt 2

HCID 65578Oxalyl chlorideHCID 6976402-(Furan-2-yl)quinoline-4-carboxylic acid

Produkt 1

HCID 106349112-(2-furyl)quinoline-4-carbonyl ChlorideAusbeute 100,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
-10 °C

Versuchsvorschrift

5.2 ml (60.4 mmol) of oxalyl chloride were dissolved in 70 ml of CH2Cl2. The solution was cooled at −10° C. and 8.5 g (35.5 mmol) of 2-(2-furyl)quinoline-4-carboxylic acid were added portionwise. The reaction mixture was left overnight at room temperature and then evaporated to dryness to yield 9.2 g of the title compound, used without further purification.

Aufarbeitung

  1. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-40299ccc2b3b4906ba7cccf3ddcf187b
Quelldatensatz
uspto-grants-2003_08
Patentnummer
US06608083B1

Notizen zur Reaktion

Wird geladen…