Ammonium Hydroxide → 3-Chloro-4-fluorobenzenesulfonamide

HRID 396805Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 396805
[Cl:1][C:2]1[CH:3]=[C:4]([S:9](Cl)(=[O:11])=[O:10])[CH:5]=[CH:6][C:7]=1[F:8].[OH-].[NH4+:14]>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([NH2:14])(=[O:11])=[O:10])[CH:5]=[CH:6][C:7]=1[F:8]

Komponenten

4

Edukt 2

HCID 14923Ammonium HydroxideHCID 1452223-Chloro-4-fluorobenzenesulphonyl chloride

Produkt 1

HCID 75098833-Chloro-4-fluorobenzenesulfonamideAusbeute 68,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 3-chloro-4-fluorobenzenesulfonyl chloride (2.29 g, 10 mmol) in methylene chloride (30 mL) was added 25% ammonium hydroxide (10 mL) at room temperature and the mixture was stirred for 1 hour. The solvent was removed in vacuo. The residue was redissolved in ethyl acetate (50 mL) and the whole washed with water and brine. After dried over MgSO4 and concentration in vacuo. The resulting solid was recrystallized from ether-hexane to give the title compound (1.429 g, 68.2% yield).

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. dissolutionThe residue was redissolved in ethyl acetate (50 mL)
  3. washthe whole washed with water and brine
  4. dry with materialAfter dried over MgSO4 and concentration in vacuo
  5. customThe resulting solid was recrystallized from ether-hexane

Quellen und Nachweise

ORD-Eintrag
ord-35ed3c7eae97476587ee23a525a81a07
Quelldatensatz
uspto-grants-2003_08
Patentnummer
US06608095B2

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