Bromine → 2-Bromo-1-(3-fluoro-4-hydroxyphenyl)ethan-1-one

HRID 396857Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 396857
[F:1][C:2]1[CH:3]=[C:4]([C:9](=[O:11])[CH3:10])[CH:5]=[CH:6][C:7]=1[OH:8].[Br:12]Br>O1CCOCC1>[Br:12][CH2:10][C:9]([C:4]1[CH:5]=[CH:6][C:7]([OH:8])=[C:2]([F:1])[CH:3]=1)=[O:11]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 27373251-(3-Fluoro-4-hydroxyphenyl)ethan-1-one

Produkt 1

HCID 179235302-Bromo-1-(3-fluoro-4-hydroxyphenyl)ethan-1-oneAusbeute 99,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel2×

Versuchsvorschrift

To a stirred solution of 1-(3-fluoro-4-hydroxyphenyl)-1-ethanone (2.0 g, 12.98 mmol) in dioxane (3 ml) was added a solution of bromine (2.09 g, 13.1 mmol) in dioxane (12 ml), and the mixture was stirred for 16 hours. The mixture was concentrated in vacuo to give title compound (3.02 g, 99% yield). The compound was used for next reaction without purification.

Aufarbeitung

  1. concentrationThe mixture was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-9b054bf0d4274235a764f4f5b17b9047
Quelldatensatz
uspto-grants-2003_08
Patentnummer
US06608095B2

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