N-Iodosuccinimide → 6-cyclopropoxy-8-iodo-2,3-dihydro-1H-3a-aza-cyclopenta[a]indene

HRID 397320Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 397320
[I:1]N1C(=O)CCC1=O.[CH:9]1([O:12][C:13]2[CH:21]=[CH:20][C:19]3[N:18]4[CH2:22][CH2:23][CH2:24][C:17]4=[CH:16][C:15]=3[CH:14]=2)[CH2:11][CH2:10]1>C(#N)C>[CH:9]1([O:12][C:13]2[CH:21]=[CH:20][C:19]3[N:18]4[CH2:22][CH2:23][CH2:24][C:17]4=[C:16]([I:1])[C:15]=3[CH:14]=2)[CH2:11][CH2:10]1

Komponenten

4

Edukt 2

HCID 120273N-IodosuccinimideHCID 230001076-Cyclopropoxy-2,3-dihydro-1H-3a-aza-cyclopenta[a]indene

Produkt 1

HCID 230001116-cyclopropoxy-8-iodo-2,3-dihydro-1H-3a-aza-cyclopenta[a]indeneAusbeute 72,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

18.5 g N-iodosuccinimide at 0° C. was added to a solution of 17.55 g 6-cyclopropoxy-2,3-dihydro-1H-3a-aza-cyclopenta[a]indene in acetonitrile and the mixture was stirred at this temperature for 15 min. The solid was collected by filtration, washed with cold acetonitrile and dried to constant weight to yield 20.1 g 6-cyclopropoxy-8-iodo-2,3-dihydro-1H-3a-aza-cyclopenta[a]indene as beige crystals melting at 104-105° C.

Aufarbeitung

  1. filtrationThe solid was collected by filtration
  2. washwashed with cold acetonitrile
  3. customdried to constant weight

Quellen und Nachweise

ORD-Eintrag
ord-0c9f49d70225419a963bb6fba251828d
Quelldatensatz
uspto-grants-2003_08
Patentnummer
US06610685B2

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