Sodium sulfite heptahydrate → Sodium tetrahydrofuran-3-ylmethanesulfonate

HRID 397647Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 397647
O.O.O.O.O.O.O.[S:8]([O-:11])([O-:10])=[O:9].[Na+:12].[Na+].Br[CH2:15][CH:16]1[CH2:20][CH2:19][O:18][CH2:17]1>O1CCOCC1.O>[O:18]1[CH2:19][CH2:20][CH:16]([CH2:15][S:8]([O-:11])(=[O:10])=[O:9])[CH2:17]1.[Na+:12]

Komponenten

5

Edukt 2

HCID 160916Sodium sulfite heptahydrateHCID 141734223-(Bromomethyl)oxolane

Produkt 1

HCID 23670188Sodium tetrahydrofuran-3-ylmethanesulfonateAusbeute 57 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

Sodium sulfite heptahydrate (6.10 g) was added to a solution of 3-(bromomethyl)tetrahydrofuran (2.0 g) [see Preparation 9] in 1,4-dioxane (9 ml) and water (9 ml). The reaction mixture was then heated under reflux and stirred for 18 hours, cooled and the solvent removed under reduced pressure. The resulting solid was dissolved in water and concentrated to a low volume. The solid formed was then collected to afford sodium tetrahydrofuran-3-ylmethanesulfonate (1.30 g) as a white solid.

Aufarbeitung

  1. temperatureThe reaction mixture was then heated
  2. temperatureunder reflux
  3. temperaturecooled
  4. customthe solvent removed under reduced pressure
  5. dissolutionThe resulting solid was dissolved in water
  6. concentrationconcentrated to a low volume
  7. customThe solid formed
  8. customwas then collected

Quellen und Nachweise

ORD-Eintrag
ord-2745747e256148b3a074e2b0bb6aa496
Quelldatensatz
uspto-grants-2003_08
Patentnummer
US06610707B1

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