Acetic Acid → HCID 23444975, Verbindung

HRID 397916Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 397916
[F:1][C:2]([C:5]1[CH:6]=[C:7]([NH2:12])[CH:8]=[CH:9][C:10]=1[F:11])([F:4])[CH3:3].C([O:20][CH2:21][CH3:22])(OCC)OCC.[N+:23]([CH2:26]C(OCC)=O)([O-])=O.[C:32](O)(=O)C>[Fe]>[F:4][C:2]([C:5]1[CH:6]=[C:7]([N:12]2[CH:32]=[C:22]([CH2:21][OH:20])[N:23]=[CH:26]2)[CH:8]=[CH:9][C:10]=1[F:11])([F:1])[CH3:3]

Komponenten

6

Edukt 4

HCID 176Acetic Acid2×HCID 31214Ethyl orthoformate2×HCID 69379Ethyl nitroacetateHCID 23445006Benzenamine, 3-(1,1-difluoroethyl)-4-fluoro-

Produkt 1

HCID 23444975HCID 23444975, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23925IronKatalysator

Versuchsvorschrift

Following the general method described in example 293, 3-(1,1-difluoro-ethyl)-4-fluorophenylamine was reacted with triethyl orthoformate, ethyl nitroacetate and acetic acid followed by treatment with triethyl orthoformate, iron and acetic acid and subsequent alkaline hydrolysis. The isolated acid was directly reduced according to example 264, by reaction with BH3 THF complex followed by hydrolytic workup and the title compound was obtained as a white crystalline solid. MS: m/e=257 (M+H+).

Aufarbeitung

  1. customThe isolated acid was directly reduced according to example 264, by reaction with BH3 THF complex

Quellen und Nachweise

ORD-Eintrag
ord-31eda07a49634b14810c7d1ea880e3b8
Quelldatensatz
uspto-grants-2003_08
Patentnummer
US06610723B2

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